The goal of treatment is to primarily prevent the clot from growing, to ensure that it does not break off and lead to pulmonary embolism and to reduce the severity of long-term post-thrombotic syndrome.

The standard of care in the management of DVT is blood thinners (anticoagulation) and compression therapy. Modern minimal invasive techniques can nowadays be offered (in addition to blood thinners and compression) in selected patients with severe symptoms (e.g. significant leg swelling and pain).

These techniques involve immediate clot removal ("clot-busters" - thrombolysis).